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This study elucidates the non-selective activation mechanism by determining cryo-EM structures of Cagri bound to AMYR-G and CTR-G complexes

These findings suggest bidirectional communication through neurotransmitter signaling, in which both the brain and commensal microbes can regulate the gastrointestinal tract as well as responses to gastrointestinal inflammation

The published proof of concept trial did not find significant differences in its key efficacy analyses

Plant Physiol 142: 775-787 Chen Z, Gallie DR (2008) Dehydroascorbate reductase affects non-photochemical quenching and photosynthetic performance

Its stability supports widespread application in functional foods like kimchi and yogurt (67)